| Registro completo |
| Provedor de dados: |
BJID
|
| País: |
Brazil
|
| Título: |
Acute HIV infection with rapid progression to AIDS
|
| Autores: |
Silva,Marcio de Oliveira
Bastos,Milena
Martins Netto,Eduardo
Gouvea,Nancy Alves de Lima
Torres,Alex Jose Leite
Kallas,Esper
Watkins,David I
Altfeld,Marcus
Brites,Carlos
|
| Data: |
2010-06-01
|
| Ano: |
2010
|
| Palavras-chave: |
HIV
Acute infection
Progression
AIDS
|
| Resumo: |
Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.
|
| Tipo: |
Info:eu-repo/semantics/report
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300016
|
| Editor: |
Brazilian Society of Infectious Diseases
|
| Relação: |
10.1590/S1413-86702010000300016
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Journal of Infectious Diseases v.14 n.3 2010
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
